Veterinary : Transdermal Medications
Have you ever thought about applying a transdermal preparation to the
inside of an animal's ear or another hairless area as an alternate
route of systemic administration? It's quick and easy, and many
medications are compatible with transdermal bases. Transdermal
delivery is particularly useful for animals who should not be stressed
due to cardiovascular or hypertensive illness. Also, it is appreciated
by owners who no longer have to deal with an animal who resists
being medicated, and the resulting scratches! We can also prepare
topical medications for application at the site of inflammation
Advantages of Transdermal Dosage Forms
Various alternative dosage forms permit medication to be absorbed
via non-oral routes to meet an animal’s specific needs.
Although the parenteral and rectal routes are traditional alternatives
to oral administration, transdermal absorption offers many advantages.
- When medication is absorbed directly into the bloodstream without first entering
the gastrointestinal system, a smaller amount of active ingredient may be
required for therapeutic effect.
- Direct application and absorption at the target site can mean higher tissue
levels and lower blood levels of various medications. Side effects such as
GI irritation can be eliminated.
- Various types of drug interactions may be avoided when one or more interacting
medications are administered transdermally.
A substantial number of references exist in human medical literature
with regard to the efficacy of transdermal administration of
non-steroidal anti-inflammatory drugs and other types of analgesics,
antiemetics, and other medications. We can compound transdermal
and topical medications using a suitable base, and add penetrant
enhancers if desired.